宗座平信徒、家庭和生命部與羅馬教區於2021年4月22日介紹了第十屆世界家庭大會的正式祈禱文。本屆大會將於2022年6月22日至26日在羅馬舉行，教宗方濟各為此選擇的主題為「家庭之愛：聖召與成聖之路」。聖座該部門部長法雷爾（Kevin Joseph Farrell）樞機表示，「祈禱是積極進入『愛的喜樂家庭年』並為羅馬家庭大會做準備的一種方法。許多家庭和團體長久以來期盼能攜手同行，至少在精神上如此。祈禱將能伴隨它們，並協助它們理解大會的訊息」。
祈禱將是這個準備進程的核心，引領工作並激發省思，好能在信德的光照下分辨教會團體因疫情而在家庭方面面臨的新挑戰。為此，教宗羅馬教區代理主教德多納蒂斯（Angelo De Donatis）樞機邀請「眾人為這個恩寵的盛會做好準備，在自己的家庭內，並與堂區和教區團體一同向上主誦唸這篇祈禱文」。禱詞如下:
Heavenly Father, We come before You to praise You and to thank You for the great gift of the family. We pray to You for all families consecrated by the Sacrament of Matrimony.
May they rediscover each day the grace they have received, and as small domestic Churches, may they know how to witness to Your presence and to the love with which Christ loves the Church.
We pray to You for all families faced with difficulty and suffering caused by illness or circumstances of which only You know. Sustain them and make them aware of the path to holiness upon which You call them, so that they might experience Your infinite mercy and find new ways to grow in love.
We pray to You for children and young people: may they encounter You and respond joyfully to the vocation You have in mind for them; We pray for parents and grandparents: may they be aware that they are signs of the fatherhood and motherhood of God in caring for the children who, in body and spirit, You entrust to them; and for the experience of fraternity that the family can give to the world.
Lord, grant that each family might live their specific vocation to holiness in the Church as a call to become missionary disciples, in the service of life and peace, in communion with our priests, religious, and all vocations in the Church. Bless the World Meeting of Families.